Sor Juana died of illness during a plague outbreak on April 17, 1695, in Mexico City.
Sor Juana Inés de la Cruz succumbed to a plague epidemic on April 17, 1695, in Mexico City, after caring for her fellow nuns in the Convent of San Jerónimo. She was approximately forty-four years old. Her death marked the end of an extraordinary life dedicated to intellectual and artistic achievement. Even in her final moments, Sor Juana demonstrated remarkable compassion and selflessness, attending to those around her despite the deadly outbreak. Her passing left an indelible void in the cultural landscape of New Spain but also solidified her legacy as a pioneering figure in literature and women's rights advocacy.