On May 21, 2023, Whitson became the first woman to command a private astronaut mission with Axiom Mission 2.
On May 21, 2023, Peggy Whitson launched as the commander of Axiom Mission 2 (Ax-2), becoming the first woman to command a private astronaut mission. This mission represents a new era of space exploration where commercial companies facilitate human space expeditions beyond governmental agencies. Her role as commander underscored her continuing leadership in innovative space travel endeavors, symbolizing the expanding opportunities for private aerospace ventures. Whitson's involvement highlights the critical expertise and experience required in pioneering private missions and reflects the changing dynamics of space travel.